Should You Split Your GLP-1 Dose Twice Weekly to Reduce Side Effects? Evidence Review
GLP-1 medications like semaglutide and tirzepatide have transformed medical weight loss by helping patients reduce appetite, improve metabolic health, and achieve sustainable weight loss. However, side effects such as nausea, bloating, constipation, fatigue, and appetite suppression can make treatment difficult for some individuals.
One question patients commonly ask is:
“Would splitting my GLP-1 dose into two smaller injections each week reduce side effects?”
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